CITED1 [The Human Chemical-Genetic Interaction Map Project]

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======= CITED1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CITED1
  * **<color #00a2e8>Official Name</color>**: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4435|4435]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99966|Q99966]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CITED1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CITED1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CITED|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mesenchymal stem cell proliferation|
|response to interleukin-11|
|regulation of mesenchymal stem cell proliferation|
|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|negative regulation of epithelial cell differentiation involved in kidney development|
|LBD domain binding|
|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|
|negative regulation of metanephros development|
|response to interleukin-9|
|spongiotrophoblast layer development|
|response to parathyroid hormone|
|co-SMAD binding|
|response to interleukin-2|
|melanin biosynthetic process|
|melanin metabolic process|
|mesenchymal to epithelial transition|
|negative regulation of kidney development|
|negative regulation of morphogenesis of an epithelium|
|regulation of epithelial cell differentiation involved in kidney development|
|secondary metabolite biosynthetic process|
|melanocyte differentiation|
|regulation of metanephros development|
|positive regulation of transforming growth factor beta receptor signaling pathway|
|positive regulation of cellular response to transforming growth factor beta stimulus|
|response to interleukin-4|
|pigment cell differentiation|
|negative regulation of animal organ morphogenesis|
|phenol-containing compound biosynthetic process|
|response to interleukin-6|
|embryonic axis specification|
|positive regulation of stem cell proliferation|
|developmental pigmentation|
|negative regulation of epithelial cell differentiation|
|negative regulation of osteoblast differentiation|
|branching involved in ureteric bud morphogenesis|
|labyrinthine layer development|
|pigment biosynthetic process|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|secondary metabolic process|
|SMAD protein signal transduction|
|embryonic pattern specification|
|pigment metabolic process|
|nephron tubule morphogenesis|
|regulation of stem cell proliferation|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|vasculogenesis|
|negative regulation of ossification|
|response to estrogen|
|nephron tubule development|
|renal tubule development|
|metanephros development|
|phenol-containing compound metabolic process|
|kidney morphogenesis|
|axis specification|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|embryonic placenta development|
|mesonephros development|
|pigmentation|
|nephron epithelium development|
|response to cAMP|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of osteoblast differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|response to organophosphorus|
|regulation of epithelial cell differentiation|
|negative regulation of neuron apoptotic process|
|placenta development|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|morphogenesis of a branching epithelium|
|response to transforming growth factor beta|
|morphogenesis of a branching structure|
|regulation of morphogenesis of an epithelium|
|response to interferon-gamma|
|organic hydroxy compound biosynthetic process|
|protein C-terminus binding|
|regulation of ossification|
|response to interleukin-1|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|negative regulation of Wnt signaling pathway|
|transcription regulatory region DNA binding|
|response to insulin|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of animal organ morphogenesis|
|nucleocytoplasmic transport|
|nuclear transport|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|transcription coactivator activity|
|epithelial tube morphogenesis|
|regulation of neuron death|
|response to lipopolysaccharide|
|urogenital system development|
|response to molecule of bacterial origin|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|response to peptide hormone|
|chromatin binding|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|organic hydroxy compound metabolic process|
|response to peptide|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|response to growth factor|
|tissue morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|response to bacterium|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|innate immune response|
|head development|
|tube development|
|response to lipid|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|apoptotic process|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|epithelium development|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9770
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CITED1 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>