CITED1

Gene Information

Official Symbol: CITED1
Official Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 4435
UniProt: Q99966
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009].
UniProt Summary: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:21172805}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9770
Expression level (log2 read counts): -2.69

Expression Distribution

positive regulation of mesenchymal stem cell proliferation
response to interleukin-11
regulation of mesenchymal stem cell proliferation
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
negative regulation of epithelial cell differentiation involved in kidney development
LBD domain binding
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
negative regulation of metanephros development
response to interleukin-9
spongiotrophoblast layer development
response to parathyroid hormone
co-SMAD binding
response to interleukin-2
melanin biosynthetic process
melanin metabolic process
mesenchymal to epithelial transition
negative regulation of kidney development
negative regulation of morphogenesis of an epithelium
regulation of epithelial cell differentiation involved in kidney development
secondary metabolite biosynthetic process
melanocyte differentiation
regulation of metanephros development
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cellular response to transforming growth factor beta stimulus
response to interleukin-4
pigment cell differentiation
negative regulation of animal organ morphogenesis
phenol-containing compound biosynthetic process
response to interleukin-6
embryonic axis specification
positive regulation of stem cell proliferation
developmental pigmentation
negative regulation of epithelial cell differentiation
negative regulation of osteoblast differentiation
branching involved in ureteric bud morphogenesis
labyrinthine layer development
pigment biosynthetic process
ureteric bud morphogenesis
mesonephric tubule morphogenesis
regulation of kidney development