CKM

Entrez Summary: N/A
UniProt Summary: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ATP-gua Ptrans
ATP-gua PtransN

phosphagen metabolic process
phosphocreatine metabolic process
phosphocreatine biosynthetic process
phosphagen biosynthetic process
creatine kinase activity
creatine metabolic process
cellular modified amino acid biosynthetic process
kinase activity
cellular modified amino acid metabolic process
drug metabolic process
monocarboxylic acid metabolic process
organophosphate biosynthetic process
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
phosphorylation
organonitrogen compound biosynthetic process
ATP binding
extracellular space
small molecule metabolic process