CLASP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CLASP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLASP1
  * **<color #00a2e8>Official Name</color>**: cytoplasmic linker associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23332|23332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z460|Q7Z460]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLASP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLASP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605852|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLASP N|
|HEAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centrosomal corona|
|cortical microtubule cytoskeleton|
|negative regulation of wound healing, spreading of epidermal cells|
|basal cortex|
|regulation of basement membrane organization|
|regulation of basement membrane assembly involved in embryonic body morphogenesis|
|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|
|regulation of wound healing, spreading of epidermal cells|
|kinetochore binding|
|kinetochore microtubule|
|astral microtubule organization|
|positive regulation of extracellular matrix disassembly|
|dystroglycan binding|
|exit from mitosis|
|negative regulation of morphogenesis of an epithelium|
|regulation of extracellular matrix disassembly|
|microtubule plus-end binding|
|microtubule plus-end|
|microtubule nucleation|
|positive regulation of extracellular matrix organization|
|negative regulation of stress fiber assembly|
|negative regulation of actin filament bundle assembly|
|negative regulation of microtubule depolymerization|
|microtubule anchoring|
|regulation of microtubule depolymerization|
|positive regulation of microtubule polymerization|
|establishment of epithelial cell polarity|
|microtubule polymerization|
|establishment of mitotic spindle localization|
|positive regulation of microtubule polymerization or depolymerization|
|establishment of spindle orientation|
|spindle microtubule|
|negative regulation of microtubule polymerization or depolymerization|
|positive regulation of embryonic development|
|regulation of gastrulation|
|mitotic spindle assembly|
|regulation of extracellular matrix organization|
|establishment of spindle localization|
|spindle localization|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of protein depolymerization|
|regulation of adherens junction organization|
|negative regulation of protein complex disassembly|
|negative regulation of wound healing|
|mitotic spindle organization|
|regulation of stress fiber assembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|regulation of epithelial to mesenchymal transition|
|kinetochore|
|negative regulation of response to wounding|
|protein polymerization|
|condensed chromosome kinetochore|
|regulation of cell junction assembly|
|positive regulation of exocytosis|
|regulation of actomyosin structure organization|
|vesicle targeting|
|microtubule bundle formation|
|microtubule organizing center organization|
|regulation of actin filament bundle assembly|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|regulation of protein complex disassembly|
|regulation of cell-matrix adhesion|
|establishment of cell polarity|
|positive regulation of protein polymerization|
|regulation of embryonic development|
|negative regulation of supramolecular fiber organization|
|G2/M transition of mitotic cell cycle|
|Golgi organization|
|cell cycle G2/M phase transition|
|cell cortex|
|regulation of wound healing|
|negative regulation of cytoskeleton organization|
|positive regulation of epithelial cell migration|
|mitotic nuclear division|
|spindle organization|
|regulation of response to wounding|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|membrane docking|
|regulation of morphogenesis of an epithelium|
|vesicle localization|
|regulation of microtubule cytoskeleton organization|
|regulation of G2/M transition of mitotic cell cycle|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|regulation of cell cycle G2/M phase transition|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|regulation of epithelial cell migration|
|regulation of microtubule-based process|
|regulation of exocytosis|
|regulation of protein polymerization|
|microtubule binding|
|positive regulation of protein complex assembly|
|negative regulation of cell migration|
|regulation of actin filament organization|
|mitotic cell cycle phase transition|
|negative regulation of cell motility|
|cell cycle phase transition|
|nuclear division|
|negative regulation of cellular component movement|
|organelle fission|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|cilium assembly|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|negative regulation of response to external stimulus|
|cilium organization|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|endomembrane system organization|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of cell migration|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|regulation of cell adhesion|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|regulation of secretion|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|regulation of cell motility|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|regulation of response to stress|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.11|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.85|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.7|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.75|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.84|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.93|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.01|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.02|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.14|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.15|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.19|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.21|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.38|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|3.36|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.23|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|4.26|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|4.58|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|4.73|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|5.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt6h|SUPT6H]]|0.511|
|[[:human genes:t:tuba1b|TUBA1B]]|0.499|
|[[:human genes:d:dtl|DTL]]|0.486|
|[[:human genes:m:map7d1|MAP7D1]]|0.474|
|[[:human genes:r:rfpl3|RFPL3]]|0.451|
|[[:human genes:s:slain1|SLAIN1]]|0.45|
|[[:human genes:t:tceb3c|TCEB3C]]|0.448|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.448|
|[[:human genes:p:plk1|PLK1]]|0.445|
|[[:human genes:p:polr2j3|POLR2J3]]|0.445|
|[[:human genes:p:psmd3|PSMD3]]|0.444|
|[[:human genes:k:kpnb1|KPNB1]]|0.442|
|[[:human genes:s:ssh2|SSH2]]|0.438|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.436|
|[[:human genes:s:soga1|SOGA1]]|0.422|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.42|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:g:gprin2|GPRIN2]]|0.412|
|[[:human genes:p:polr1a|POLR1A]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.409|
|[[:human genes:a:atp13a1|ATP13A1]]|0.408|
|[[:human genes:n:nup153|NUP153]]|0.402|
|[[:human genes:c:cbwd5|CBWD5]]|0.402|
|[[:human genes:c:cbwd6|CBWD6]]|0.402|
|[[:human genes:m:mt1e|MT1E]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLASP1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>