CLASP1
Gene Information
- Official Symbol: CLASP1
- Official Name: cytoplasmic linker associated protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23332
- UniProt: Q7Z460
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| CLASP N |
| HEAT |
GO Terms
| centrosomal corona |
| cortical microtubule cytoskeleton |
| negative regulation of wound healing, spreading of epidermal cells |
| basal cortex |
| regulation of basement membrane organization |
| regulation of basement membrane assembly involved in embryonic body morphogenesis |
| positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| regulation of wound healing, spreading of epidermal cells |
| kinetochore binding |
| kinetochore microtubule |
| astral microtubule organization |
| positive regulation of extracellular matrix disassembly |
| dystroglycan binding |
| exit from mitosis |
| negative regulation of morphogenesis of an epithelium |
| regulation of extracellular matrix disassembly |
| microtubule plus-end binding |
| microtubule plus-end |
| microtubule nucleation |
| positive regulation of extracellular matrix organization |
| negative regulation of stress fiber assembly |
| negative regulation of actin filament bundle assembly |
| negative regulation of microtubule depolymerization |
| microtubule anchoring |
| regulation of microtubule depolymerization |
| positive regulation of microtubule polymerization |
| establishment of epithelial cell polarity |
| microtubule polymerization |
| establishment of mitotic spindle localization |
| positive regulation of microtubule polymerization or depolymerization |
| establishment of spindle orientation |
| spindle microtubule |
| negative regulation of microtubule polymerization or depolymerization |
| positive regulation of embryonic development |
| regulation of gastrulation |
| mitotic spindle assembly |
| regulation of extracellular matrix organization |
| establishment of spindle localization |
| spindle localization |
| microtubule polymerization or depolymerization |
| regulation of microtubule polymerization |
| cytoplasmic microtubule |
| cytoplasmic microtubule organization |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| negative regulation of protein depolymerization |
| regulation of adherens junction organization |
| negative regulation of protein complex disassembly |
| negative regulation of wound healing |
| mitotic spindle organization |
| regulation of stress fiber assembly |
| regulation of microtubule polymerization or depolymerization |
| regulation of protein depolymerization |
| regulation of epithelial to mesenchymal transition |
| kinetochore |
| negative regulation of response to wounding |
| protein polymerization |
| condensed chromosome kinetochore |
| regulation of cell junction assembly |
| positive regulation of exocytosis |
| regulation of actomyosin structure organization |
| vesicle targeting |
| microtubule bundle formation |
| microtubule organizing center organization |
| regulation of actin filament bundle assembly |
| ciliary basal body-plasma membrane docking |
| spindle assembly |
| microtubule cytoskeleton organization involved in mitosis |
| regulation of protein complex disassembly |
| regulation of cell-matrix adhesion |
| establishment of cell polarity |
| positive regulation of protein polymerization |
| regulation of embryonic development |
| negative regulation of supramolecular fiber organization |
| G2/M transition of mitotic cell cycle |
| Golgi organization |
| cell cycle G2/M phase transition |
| cell cortex |
| regulation of wound healing |
| negative regulation of cytoskeleton organization |
| positive regulation of epithelial cell migration |
| mitotic nuclear division |
| spindle organization |
| regulation of response to wounding |
| organelle localization by membrane tethering |
| establishment of vesicle localization |
| membrane docking |
| regulation of morphogenesis of an epithelium |
| vesicle localization |
| regulation of microtubule cytoskeleton organization |
| regulation of G2/M transition of mitotic cell cycle |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| regulation of cell cycle G2/M phase transition |
| regulation of cell-substrate adhesion |
| positive regulation of cytoskeleton organization |
| regulation of epithelial cell migration |
| regulation of microtubule-based process |
| regulation of exocytosis |
| regulation of protein polymerization |
| microtubule binding |
| positive regulation of protein complex assembly |
| negative regulation of cell migration |
| regulation of actin filament organization |
| mitotic cell cycle phase transition |
| negative regulation of cell motility |
| cell cycle phase transition |
| nuclear division |
| negative regulation of cellular component movement |
| organelle fission |
| negative regulation of locomotion |
| regulation of actin cytoskeleton organization |
| cilium assembly |
| regulation of supramolecular fiber organization |
| establishment of organelle localization |
| negative regulation of response to external stimulus |
| cilium organization |
| negative regulation of organelle organization |
| regulation of actin filament-based process |
| positive regulation of secretion by cell |
| regulation of mitotic cell cycle phase transition |
| focal adhesion |
| endomembrane system organization |
| positive regulation of secretion |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| cell projection assembly |
| microtubule cytoskeleton organization |
| centrosome |
| cell division |
| positive regulation of cell migration |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| organelle localization |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| microtubule-based process |
| regulation of cell adhesion |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| organelle assembly |
| regulation of secretion |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| Golgi apparatus |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| regulation of response to stress |
| protein-containing complex assembly |
| negative regulation of response to stimulus |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SUPT6H | 0.511 |
| TUBA1B | 0.499 |
| DTL | 0.486 |
| MAP7D1 | 0.474 |
| RFPL3 | 0.451 |
| SLAIN1 | 0.45 |
| TCEB3C | 0.448 |
| NCKAP1L | 0.448 |
| PLK1 | 0.445 |
| POLR2J3 | 0.445 |
| PSMD3 | 0.444 |
| KPNB1 | 0.442 |
| SSH2 | 0.438 |
| TCEB3CL2 | 0.436 |
| SOGA1 | 0.422 |
| TCEB3CL | 0.42 |
| CBWD3 | 0.418 |
| GPRIN2 | 0.412 |
| POLR1A | 0.409 |
| SLC4A1 | 0.409 |
| ATP13A1 | 0.408 |
| NUP153 | 0.402 |
| CBWD5 | 0.402 |
| CBWD6 | 0.402 |
| MT1E | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A
| Tissue | Fraction Of Cell Lines Where Essential |
|---|
Essentiality in NALM6
- Essentiality Rank: 2019
- Expression level (log2 read counts): 7.02
Expression Distribution
CLASP1 Expression in NALM6 Cells: 7.02
