CLCN2 [The Human Chemical-Genetic Interaction Map Project]

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======= CLCN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLCN2
  * **<color #00a2e8>Official Name</color>**: chloride voltage-gated channel 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1181|1181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51788|P51788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLCN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLCN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO:0000269|PubMed:19153159, ECO:0000269|PubMed:19191339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Voltage CLC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell differentiation involved in salivary gland development|
|regulation of aldosterone biosynthetic process|
|regulation of aldosterone metabolic process|
|regulation of steroid hormone biosynthetic process|
|voltage-gated chloride channel activity|
|regulation of ketone biosynthetic process|
|regulation of hormone biosynthetic process|
|salivary gland development|
|regulation of hormone metabolic process|
|exocrine system development|
|chloride channel complex|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|regulation of steroid metabolic process|
|retina development in camera-type eye|
|inorganic anion transport|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|anion transmembrane transport|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|regulation of lipid metabolic process|
|gland development|
|regulation of small molecule metabolic process|
|regulation of ion transmembrane transport|
|regulation of hormone levels|
|sensory organ development|
|regulation of transmembrane transport|
|anion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|ion transmembrane transport|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.96|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.86|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.82|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.76|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.79|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLCN2 Expression in NALM6 Cells: 2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>