CLCN2

Entrez Summary: This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
UniProt Summary: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. {ECO:0000269|PubMed:19153159, ECO:0000269|PubMed:19191339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell differentiation involved in salivary gland development
regulation of aldosterone biosynthetic process
regulation of aldosterone metabolic process
regulation of steroid hormone biosynthetic process
voltage-gated chloride channel activity
regulation of ketone biosynthetic process
regulation of hormone biosynthetic process
salivary gland development
regulation of hormone metabolic process
exocrine system development
chloride channel complex
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
regulation of steroid metabolic process
retina development in camera-type eye
inorganic anion transport
regulation of cellular ketone metabolic process
regulation of lipid biosynthetic process
anion transmembrane transport
camera-type eye development
eye development
visual system development
sensory system development
regulation of lipid metabolic process
gland development
regulation of small molecule metabolic process
regulation of ion transmembrane transport
regulation of hormone levels
sensory organ development
regulation of transmembrane transport
anion transport
inorganic ion transmembrane transport
regulation of ion transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane