CLDN17

Entrez Summary: N/A
UniProt Summary: Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability. {ECO:0000269|PubMed:22402829}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
chloride channel complex
chloride channel activity
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
bicellular tight junction
inorganic anion transport
structural molecule activity
cell-cell adhesion via plasma-membrane adhesion molecules
anion transmembrane transport
cell-cell adhesion
anion transport
inorganic ion transmembrane transport
cell adhesion
biological adhesion
ion transmembrane transport
identical protein binding
transmembrane transport
ion transport