CLDN18 [The Human Chemical-Genetic Interaction Map Project]

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======= CLDN18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLDN18
  * **<color #00a2e8>Official Name</color>**: claudin 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51208|51208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56856|P56856]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLDN18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLDN18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TNFSF11-mediated signaling pathway|
|negative regulation of osteoclast development|
|negative regulation of bone development|
|regulation of osteoclast development|
|negative regulation of bone resorption|
|negative regulation of bone remodeling|
|negative regulation of tissue remodeling|
|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|
|regulation of bone development|
|negative regulation of osteoclast differentiation|
|negative regulation of protein localization to nucleus|
|regulation of bone resorption|
|negative regulation of myeloid leukocyte differentiation|
|regulation of bone remodeling|
|regulation of osteoclast differentiation|
|regulation of tissue remodeling|
|negative regulation of myeloid cell differentiation|
|negative regulation of leukocyte differentiation|
|negative regulation of cellular protein localization|
|regulation of myeloid leukocyte differentiation|
|regulation of protein localization to nucleus|
|tumor necrosis factor-mediated signaling pathway|
|bicellular tight junction|
|response to ethanol|
|digestive tract development|
|negative regulation of hemopoiesis|
|digestive system development|
|structural molecule activity|
|regulation of myeloid cell differentiation|
|response to alcohol|
|cellular response to tumor necrosis factor|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|response to tumor necrosis factor|
|regulation of leukocyte differentiation|
|response to antibiotic|
|negative regulation of cell development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|cell-cell adhesion|
|response to toxic substance|
|regulation of cellular protein localization|
|cytokine-mediated signaling pathway|
|negative regulation of cell differentiation|
|tube development|
|regulation of cellular localization|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cellular response to cytokine stimulus|
|response to drug|
|regulation of protein localization|
|identical protein binding|
|response to cytokine|
|negative regulation of multicellular organismal process|
|response to oxygen-containing compound|
|regulation of immune system process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLDN18 Expression in NALM6 Cells: 1.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>