CLDN18

Gene Information

Official Symbol: CLDN18
Official Name: claudin 18
Aliases and Previous Symbols: N/A
Entrez ID: 51208
UniProt: P56856
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8825
Expression level (log2 read counts): 1.21

Expression Distribution

TNFSF11-mediated signaling pathway
negative regulation of osteoclast development
negative regulation of bone development
regulation of osteoclast development
negative regulation of bone resorption
negative regulation of bone remodeling
negative regulation of tissue remodeling
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
regulation of bone development
negative regulation of osteoclast differentiation
negative regulation of protein localization to nucleus
regulation of bone resorption
negative regulation of myeloid leukocyte differentiation
regulation of bone remodeling
regulation of osteoclast differentiation
regulation of tissue remodeling
negative regulation of myeloid cell differentiation
negative regulation of leukocyte differentiation
negative regulation of cellular protein localization
regulation of myeloid leukocyte differentiation
regulation of protein localization to nucleus
tumor necrosis factor-mediated signaling pathway
bicellular tight junction
response to ethanol
digestive tract development
negative regulation of hemopoiesis
digestive system development
structural molecule activity
regulation of myeloid cell differentiation
response to alcohol
cellular response to tumor necrosis factor
cell-cell adhesion via plasma-membrane adhesion molecules
response to tumor necrosis factor
regulation of leukocyte differentiation
response to antibiotic
negative regulation of cell development
negative regulation of immune system process
regulation of hemopoiesis
cell-cell adhesion
response to toxic substance