CLDN3

Entrez Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

apicolateral plasma membrane
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
epithelial cell morphogenesis
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
lateral plasma membrane
cell-cell junction assembly
protein heterooligomerization
bicellular tight junction
response to ethanol
transmembrane signaling receptor activity
cell-cell junction organization
cell junction assembly
structural molecule activity
epithelial cell development
cell junction organization
response to alcohol
cell-cell adhesion via plasma-membrane adhesion molecules
response to antibiotic
protein homooligomerization
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
cell-cell adhesion
response to toxic substance
protein complex oligomerization
cell morphogenesis involved in differentiation
epithelial cell differentiation
cell morphogenesis
cellular component morphogenesis
cell adhesion
biological adhesion
response to drug
identical protein binding
epithelium development
response to abiotic stimulus
integral component of plasma membrane
response to oxygen-containing compound