CLDN5 [The Human Chemical-Genetic Interaction Map Project]

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======= CLDN5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLDN5
  * **<color #00a2e8>Official Name</color>**: claudin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7122|7122]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00501|O00501]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLDN5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLDN5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602101|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial cell development|
|positive regulation of establishment of endothelial barrier|
|regulation of establishment of endothelial barrier|
|regulation of endothelial cell development|
|positive regulation of endothelial cell differentiation|
|apicolateral plasma membrane|
|regulation of bicellular tight junction assembly|
|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|
|face morphogenesis|
|regulation of endothelial cell differentiation|
|head morphogenesis|
|body morphogenesis|
|face development|
|cortical actin cytoskeleton|
|positive regulation of epithelial cell differentiation|
|outflow tract morphogenesis|
|regulation of cell junction assembly|
|roof of mouth development|
|transforming growth factor beta receptor signaling pathway|
|cell-cell junction assembly|
|bicellular tight junction|
|cell-cell junction organization|
|regulation of epithelial cell differentiation|
|learning|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cell junction assembly|
|cell-cell junction|
|structural molecule activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell junction organization|
|heart morphogenesis|
|learning or memory|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cognition|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|heart development|
|response to growth factor|
|positive regulation of cell development|
|cell junction|
|behavior|
|enzyme linked receptor protein signaling pathway|
|head development|
|circulatory system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|identical protein binding|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|nervous system process|
|response to endogenous stimulus|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.08|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLDN5 Expression in NALM6 Cells: -0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>