CLDN5

Entrez Summary: N/A
UniProt Summary: Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Metformin 40μM R03 exp132	-2.08
Benzoate 20000μM R08 exp456	-1.76

positive regulation of endothelial cell development
positive regulation of establishment of endothelial barrier
regulation of establishment of endothelial barrier
regulation of endothelial cell development
positive regulation of endothelial cell differentiation
apicolateral plasma membrane
regulation of bicellular tight junction assembly
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
face morphogenesis
regulation of endothelial cell differentiation
head morphogenesis
body morphogenesis
face development
cortical actin cytoskeleton
positive regulation of epithelial cell differentiation
outflow tract morphogenesis
regulation of cell junction assembly
roof of mouth development
transforming growth factor beta receptor signaling pathway
cell-cell junction assembly
bicellular tight junction
cell-cell junction organization
regulation of epithelial cell differentiation
learning
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
cell junction assembly
cell-cell junction
structural molecule activity
transmembrane receptor protein serine/threonine kinase signaling pathway
cell junction organization
heart morphogenesis
learning or memory
cell-cell adhesion via plasma-membrane adhesion molecules
cognition
cellular response to growth factor stimulus
cell-cell adhesion
heart development
response to growth factor
positive regulation of cell development