CLEC12B

Gene Information

Official Symbol: CLEC12B
Official Name: C-type lectin domain family 12 member B
Aliases and Previous Symbols: N/A
Entrez ID: 387837
UniProt: Q2HXU8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. {ECO:0000269|PubMed:17562706}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18296
Expression level (log2 read counts): 3.61

Expression Distribution

Screen	Score
PNU96415E 10μM R03 exp145	1.74
Lead acetate 990μM R08 exp496	2.31

Ly49
Lectin C

natural killer cell inhibitory signaling pathway
receptor inhibitor activity
immune response-inhibiting cell surface receptor signaling pathway
immune response-inhibiting signal transduction
negative regulation of natural killer cell mediated cytotoxicity
negative regulation of natural killer cell mediated immunity
negative regulation of leukocyte mediated cytotoxicity
negative regulation of cell killing
negative regulation of lymphocyte mediated immunity
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
negative regulation of leukocyte mediated immunity
negative regulation of innate immune response
negative regulation of signaling receptor activity
regulation of leukocyte mediated cytotoxicity
protein phosphatase binding
negative regulation of response to biotic stimulus
regulation of cell killing
negative regulation of immune effector process
negative regulation of immune response
regulation of lymphocyte mediated immunity
regulation of signaling receptor activity
carbohydrate binding
regulation of leukocyte mediated immunity
negative regulation of defense response
negative regulation of multi-organism process
negative regulation of response to external stimulus
external side of plasma membrane
negative regulation of immune system process
regulation of innate immune response
regulation of immune effector process
immune response-regulating cell surface receptor signaling pathway
regulation of response to biotic stimulus
immune response-regulating signaling pathway
protein-containing complex
regulation of defense response
regulation of multi-organism process
regulation of response to external stimulus
negative regulation of molecular function
regulation of immune response