CLEC4C [The Human Chemical-Genetic Interaction Map Project]

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======= CLEC4C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLEC4C
  * **<color #00a2e8>Official Name</color>**: C-type lectin domain family 4 member C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=170482|170482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTT0|Q8WTT0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLEC4C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLEC4C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606677|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non- sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen- processing and peptide-loading compartments for presentation to T- cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719, ECO:0000269|PubMed:25995448}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ficolin-1-rich granule membrane|
|tertiary granule membrane|
|secretory granule membrane|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|carbohydrate binding|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|exocytosis|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|regulation of immune system process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.09|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.98|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.88|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.87|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.79|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.75|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.83|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.85|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14105
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLEC4C Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>