CLEC4C

Entrez Summary: N/A
UniProt Summary: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non- sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen- processing and peptide-loading compartments for presentation to T- cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719, ECO:0000269|PubMed:25995448}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ficolin-1-rich granule membrane
tertiary granule membrane
secretory granule membrane
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
carbohydrate binding
innate immune response-activating signal transduction
activation of innate immune response
positive regulation of innate immune response
positive regulation of response to biotic stimulus
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
positive regulation of multi-organism process
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
regulation of response to biotic stimulus
immune response-activating signal transduction
myeloid leukocyte activation
immune response-regulating signaling pathway
positive regulation of response to external stimulus
adaptive immune response
leukocyte activation involved in immune response
cell activation involved in immune response
activation of immune response
regulated exocytosis
regulation of defense response
leukocyte mediated immunity
innate immune response
regulation of multi-organism process
exocytosis
positive regulation of immune response
leukocyte activation