CLEC4E

Gene Information

Official Symbol: CLEC4E
Official Name: C-type lectin domain family 4 member E
Aliases and Previous Symbols: N/A
Entrez ID: 26253
UniProt: Q9ULY5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:18509109}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12372
Expression level (log2 read counts): 1.19

Expression Distribution

pattern recognition receptor activity
T cell differentiation involved in immune response
T cell activation involved in immune response
lymphocyte activation involved in immune response
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
pattern recognition receptor signaling pathway
T cell differentiation
positive regulation of cytokine secretion
Fc-gamma receptor signaling pathway
carbohydrate binding
regulation of cytokine secretion
innate immune response-activating signal transduction
T cell activation
lymphocyte differentiation
Fc receptor signaling pathway
activation of innate immune response
positive regulation of protein secretion
positive regulation of peptide secretion
defense response to bacterium
leukocyte differentiation
positive regulation of innate immune response
positive regulation of response to biotic stimulus
lymphocyte activation
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
immune response-activating cell surface receptor signaling pathway
positive regulation of cytokine production
regulation of innate immune response
positive regulation of establishment of protein localization
regulation of protein secretion
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
regulation of peptide secretion
positive regulation of multi-organism process
regulation of response to biotic stimulus
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway