CLEC4G [The Human Chemical-Genetic Interaction Map Project]

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======= CLEC4G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLEC4G
  * **<color #00a2e8>Official Name</color>**: C-type lectin domain family 4 member G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339390|339390]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UXB4|Q6UXB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLEC4G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLEC4G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616256|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. {ECO:0000269|PubMed:14711836}. (Microbial infection) Acts as a receptor for Ebolavirus. {ECO:0000269|PubMed:16051304}. (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088). {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysaccharide binding|
|negative regulation of T cell mediated immunity|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|negative regulation of T cell proliferation|
|regulation of T cell mediated immunity|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|virus receptor activity|
|negative regulation of leukocyte proliferation|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of lymphocyte activation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|interaction with host|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|viral life cycle|
|regulation of leukocyte mediated immunity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of immune response|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.75|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.84|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.98|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLEC4G Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>