CLEC4G

Gene Information

Official Symbol: CLEC4G
Official Name: C-type lectin domain family 4 member G
Aliases and Previous Symbols: N/A
Entrez ID: 339390
UniProt: Q6UXB4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. {ECO:0000269|PubMed:14711836}. (Microbial infection) Acts as a receptor for Ebolavirus. {ECO:0000269|PubMed:16051304}. (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein (PubMed:22156524, PubMed:22673088). {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN racemic mixture R03 exp93	-1.75
L-BMAA 500 to 750μM on day4 R04 exp185	1.84
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.98
CHIR-124 0.04μM R06 exp272	2.01

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5538
Expression level (log2 read counts): -2.35

Expression Distribution

polysaccharide binding
negative regulation of T cell mediated immunity
negative regulation of lymphocyte mediated immunity
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of adaptive immune response
negative regulation of leukocyte mediated immunity
negative regulation of T cell proliferation
regulation of T cell mediated immunity
negative regulation of lymphocyte proliferation
negative regulation of mononuclear cell proliferation
virus receptor activity
negative regulation of leukocyte proliferation
viral entry into host cell
entry into host
entry into host cell
negative regulation of T cell activation
negative regulation of immune effector process
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte activation
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of immune response
regulation of lymphocyte mediated immunity
interaction with host
regulation of T cell proliferation
regulation of adaptive immune response
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
negative regulation of cell activation
viral life cycle
regulation of leukocyte mediated immunity
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
negative regulation of cell adhesion
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
regulation of cell-cell adhesion
negative regulation of immune system process
regulation of immune effector process
regulation of lymphocyte activation