CLEC5A

Entrez Summary: N/A
UniProt Summary: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. {ECO:0000250, ECO:0000269|PubMed:10449773}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of myeloid cell apoptotic process
osteoblast development
regulation of myeloid cell apoptotic process
cellular defense response
tertiary granule membrane
virus receptor activity
specific granule membrane
viral entry into host cell
entry into host
entry into host cell
osteoblast differentiation
positive regulation of cytokine secretion
interaction with host
carbohydrate binding
viral life cycle
regulation of cytokine secretion
myeloid cell differentiation
ossification
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
neutrophil degranulation
neutrophil activation involved in immune response
regulation of peptide secretion
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
hemopoiesis
myeloid leukocyte activation
hematopoietic or lymphoid organ development
cell surface
leukocyte activation involved in immune response