CLEC6A

Gene Information

Official Symbol: CLEC6A
Official Name: C-type lectin domain containing 6A
Aliases and Previous Symbols: N/A
Entrez ID: 93978
UniProt: Q6EIG7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14544
Expression level (log2 read counts): -2.31

Expression Distribution

mannose binding
defense response to fungus
response to fungus
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
positive regulation of cytokine secretion
carbohydrate binding
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cytokine secretion
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
activation of innate immune response
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of innate immune response
positive regulation of response to biotic stimulus
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
immune response-activating cell surface receptor signaling pathway
positive regulation of cytokine production
regulation of innate immune response
positive regulation of establishment of protein localization
regulation of protein secretion
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
regulation of peptide secretion
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
adaptive immune response
activation of immune response
regulation of cytokine production
regulation of protein transport
calcium ion binding
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell