CLEC7A [The Human Chemical-Genetic Interaction Map Project]

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======= CLEC7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLEC7A
  * **<color #00a2e8>Official Name</color>**: C-type lectin domain containing 7A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64581|64581]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXN2|Q9BXN2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLEC7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLEC7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Herpes UL45|
|Lectin C|
|Ly49|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of molecule of fungal origin|
|detection of fungus|
|(1->3)-beta-D-glucan binding|
|cellular response to molecule of fungal origin|
|response to molecule of fungal origin|
|positive regulation of interleukin-10 biosynthetic process|
|carbohydrate mediated signaling|
|regulation of interleukin-10 biosynthetic process|
|positive regulation of interleukin-12 biosynthetic process|
|regulation of interleukin-12 biosynthetic process|
|MHC protein binding|
|positive regulation of respiratory burst|
|positive regulation of cell maturation|
|signaling pattern recognition receptor activity|
|positive regulation of monocyte chemotactic protein-1 production|
|positive regulation of interleukin-8 biosynthetic process|
|positive regulation of interleukin-2 biosynthetic process|
|positive regulation of interferon-gamma biosynthetic process|
|positive regulation of killing of cells of other organism|
|detection of other organism|
|positive regulation of interleukin-6 biosynthetic process|
|regulation of interleukin-8 biosynthetic process|
|regulation of monocyte chemotactic protein-1 production|
|regulation of respiratory burst|
|regulation of killing of cells of other organism|
|regulation of interferon-gamma biosynthetic process|
|positive regulation of cytokine production involved in inflammatory response|
|detection of external biotic stimulus|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of superoxide anion generation|
|positive regulation of tumor necrosis factor biosynthetic process|
|regulation of superoxide anion generation|
|defense response to protozoan|
|detection of biotic stimulus|
|regulation of interleukin-6 biosynthetic process|
|regulation of cell maturation|
|response to protozoan|
|regulation of tumor necrosis factor biosynthetic process|
|positive regulation of interleukin-2 production|
|regulation of superoxide metabolic process|
|positive regulation of interleukin-12 production|
|positive regulation of interleukin-10 production|
|positive regulation of nitric oxide biosynthetic process|
|positive regulation of nitric oxide metabolic process|
|regulation of cytokine production involved in inflammatory response|
|positive regulation of interleukin-8 production|
|response to fungus|
|positive regulation of reactive oxygen species biosynthetic process|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-10 production|
|regulation of interleukin-12 production|
|positive regulation of wound healing|
|regulation of interleukin-2 production|
|regulation of nitric oxide biosynthetic process|
|positive regulation of chemokine production|
|positive regulation of interleukin-1 production|
|positive regulation of interferon-gamma production|
|positive regulation of response to wounding|
|positive regulation of cell killing|
|positive regulation of cytokine biosynthetic process|
|positive regulation of phagocytosis|
|regulation of interleukin-8 production|
|regulation of chemokine production|
|cellular response to carbohydrate stimulus|
|regulation of interleukin-1 beta production|
|positive regulation of tumor necrosis factor production|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|regulation of phagocytosis|
|positive regulation of reactive oxygen species metabolic process|
|regulation of interferon-gamma production|
|regulation of cell killing|
|regulation of cytokine biosynthetic process|
|phagocytosis, recognition|
|pattern recognition receptor signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of wound healing|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of response to wounding|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|carbohydrate binding|
|regulation of reactive oxygen species metabolic process|
|positive regulation of peptidase activity|
|cellular response to biotic stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|innate immune response-activating signal transduction|
|T cell activation|
|cell recognition|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|activation of innate immune response|
|phagocytosis|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|positive regulation of cell motility|
|detection of chemical stimulus|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|endocytosis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|import into cell|
|intracellular membrane-bounded organelle|
|detection of stimulus|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to oxygen-containing compound|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17726
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLEC7A Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>