CLEC7A
Gene Information
- Official Symbol: CLEC7A
- Official Name: C-type lectin domain containing 7A
- Aliases and Previous Symbols: N/A
- Entrez ID: 64581
- UniProt: Q9BXN2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Herpes UL45 |
| Lectin C |
| Ly49 |
GO Terms
| detection of molecule of fungal origin |
| detection of fungus |
| (1→3)-beta-D-glucan binding |
| cellular response to molecule of fungal origin |
| response to molecule of fungal origin |
| positive regulation of interleukin-10 biosynthetic process |
| carbohydrate mediated signaling |
| regulation of interleukin-10 biosynthetic process |
| positive regulation of interleukin-12 biosynthetic process |
| regulation of interleukin-12 biosynthetic process |
| MHC protein binding |
| positive regulation of respiratory burst |
| positive regulation of cell maturation |
| signaling pattern recognition receptor activity |
| positive regulation of monocyte chemotactic protein-1 production |
| positive regulation of interleukin-8 biosynthetic process |
| positive regulation of interleukin-2 biosynthetic process |
| positive regulation of interferon-gamma biosynthetic process |
| positive regulation of killing of cells of other organism |
| detection of other organism |
| positive regulation of interleukin-6 biosynthetic process |
| regulation of interleukin-8 biosynthetic process |
| regulation of monocyte chemotactic protein-1 production |
| regulation of respiratory burst |
| regulation of killing of cells of other organism |
| regulation of interferon-gamma biosynthetic process |
| positive regulation of cytokine production involved in inflammatory response |
| detection of external biotic stimulus |
| regulation of interleukin-2 biosynthetic process |
| positive regulation of superoxide anion generation |
| positive regulation of tumor necrosis factor biosynthetic process |
| regulation of superoxide anion generation |
| defense response to protozoan |
| detection of biotic stimulus |
| regulation of interleukin-6 biosynthetic process |
| regulation of cell maturation |
| response to protozoan |
| regulation of tumor necrosis factor biosynthetic process |
| positive regulation of interleukin-2 production |
| regulation of superoxide metabolic process |
| positive regulation of interleukin-12 production |
| positive regulation of interleukin-10 production |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| regulation of cytokine production involved in inflammatory response |
| positive regulation of interleukin-8 production |
| response to fungus |
| positive regulation of reactive oxygen species biosynthetic process |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-10 production |
| regulation of interleukin-12 production |
| positive regulation of wound healing |
| regulation of interleukin-2 production |
| regulation of nitric oxide biosynthetic process |
| positive regulation of chemokine production |
| positive regulation of interleukin-1 production |
| positive regulation of interferon-gamma production |
| positive regulation of response to wounding |
| positive regulation of cell killing |
| positive regulation of cytokine biosynthetic process |
| positive regulation of phagocytosis |
| regulation of interleukin-8 production |
| regulation of chemokine production |
| cellular response to carbohydrate stimulus |
| regulation of interleukin-1 beta production |
| positive regulation of tumor necrosis factor production |
| regulation of reactive oxygen species biosynthetic process |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of interleukin-6 production |
| regulation of interleukin-1 production |
| regulation of phagocytosis |
| positive regulation of reactive oxygen species metabolic process |
| regulation of interferon-gamma production |
| regulation of cell killing |
| regulation of cytokine biosynthetic process |
| phagocytosis, recognition |
| pattern recognition receptor signaling pathway |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of wound healing |
| positive regulation of inflammatory response |
| regulation of interleukin-6 production |
| regulation of tumor necrosis factor production |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of response to wounding |
| response to carbohydrate |
| positive regulation of endopeptidase activity |
| carbohydrate binding |
| regulation of reactive oxygen species metabolic process |
| positive regulation of peptidase activity |
| cellular response to biotic stimulus |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| innate immune response-activating signal transduction |
| T cell activation |
| cell recognition |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| activation of innate immune response |
| phagocytosis |
| regulation of inflammatory response |
| positive regulation of innate immune response |
| regulation of neurotransmitter levels |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| regulation of innate immune response |
| positive regulation of defense response |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| detection of chemical stimulus |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| endocytosis |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cell surface |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| import into cell |
| intracellular membrane-bounded organelle |
| detection of stimulus |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of proteolysis |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| regulation of cell development |
| defense response to other organism |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to oxygen-containing compound |
| cell activation |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17726
- Expression level (log2 read counts): 3.2
Expression Distribution
CLEC7A Expression in NALM6 Cells: 3.2
