CLIP1 [The Human Chemical-Genetic Interaction Map Project]

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======= CLIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLIP1
  * **<color #00a2e8>Official Name</color>**: CAP-Gly domain containing linker protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6249|6249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30622|P30622]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP GLY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transport into plasma membrane raft|
|protein localization to plasma membrane raft|
|protein transport into membrane raft|
|protein transport within lipid bilayer|
|protein localization to membrane raft|
|macropinosome|
|microtubule plus-end binding|
|microtubule plus-end|
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|cytoplasmic microtubule|
|tubulin binding|
|regulation of microtubule polymerization or depolymerization|
|localization within membrane|
|kinetochore|
|microtubule bundle formation|
|ruffle|
|intermediate filament|
|positive regulation of protein polymerization|
|cytoplasmic vesicle membrane|
|microtubule cytoskeleton|
|nuclear envelope|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|protein localization to cell periphery|
|microtubule binding|
|positive regulation of protein complex assembly|
|establishment of protein localization to membrane|
|endosome|
|microtubule|
|regulation of supramolecular fiber organization|
|regulation of protein complex assembly|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|centrosome|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|microtubule-based process|
|mitotic cell cycle|
|zinc ion binding|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|intracellular protein transport|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.82|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLIP1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>