CLIP1

Entrez Summary: The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Selumetinib 20μM R02 exp81	-1.82
Rifampicin 30μM R08 exp430	-1.77

protein transport into plasma membrane raft
protein localization to plasma membrane raft
protein transport into membrane raft
protein transport within lipid bilayer
protein localization to membrane raft
macropinosome
microtubule plus-end binding
microtubule plus-end
positive regulation of microtubule polymerization
positive regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
cytoplasmic microtubule
tubulin binding
regulation of microtubule polymerization or depolymerization
localization within membrane
kinetochore
microtubule bundle formation
ruffle
intermediate filament
positive regulation of protein polymerization
cytoplasmic vesicle membrane
microtubule cytoskeleton
nuclear envelope
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
protein localization to cell periphery
microtubule binding
positive regulation of protein complex assembly
establishment of protein localization to membrane
endosome
microtubule
regulation of supramolecular fiber organization
regulation of protein complex assembly
microtubule cytoskeleton organization
protein localization to membrane
centrosome
positive regulation of cellular component biogenesis