CLK2

Entrez Summary: N/A
UniProt Summary: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Methotrexate 0.01μM R08 exp501	-1.76
Docetaxel 0.002μM R01 exp45	2.42

Pkinase Tyr
Pkinase

negative regulation of gluconeogenesis
protein serine/threonine/tyrosine kinase activity
negative regulation of cellular carbohydrate metabolic process
regulation of gluconeogenesis
negative regulation of carbohydrate metabolic process
protein tyrosine kinase activity
negative regulation of small molecule metabolic process
regulation of carbohydrate biosynthetic process
response to retinoic acid
regulation of glucose metabolic process
regulation of RNA splicing
regulation of cellular carbohydrate metabolic process
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
response to ionizing radiation
protein autophosphorylation
regulation of carbohydrate metabolic process
nuclear body
response to acid chemical
protein serine/threonine kinase activity
nuclear speck
regulation of small molecule metabolic process
response to radiation
response to lipid
peptidyl-amino acid modification
protein phosphorylation
identical protein binding
response to abiotic stimulus
phosphorylation
ATP binding
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
response to oxygen-containing compound