CLK3 [The Human Chemical-Genetic Interaction Map Project]

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======= CLK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLK3
  * **<color #00a2e8>Official Name</color>**: CDC like kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1198|1198]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49761|P49761]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein serine/threonine/tyrosine kinase activity|
|intermediate filament cytoskeleton|
|acrosomal vesicle|
|protein tyrosine kinase activity|
|regulation of RNA splicing|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|protein autophosphorylation|
|protein serine/threonine kinase activity|
|nuclear speck|
|peptidyl-amino acid modification|
|protein phosphorylation|
|identical protein binding|
|phosphorylation|
|RNA binding|
|ATP binding|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-5.35|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-5.21|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-3.28|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.53|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.1|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.06|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.89|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.85|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.8|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.75|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.7|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.71|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.76|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.89|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.94|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.01|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.21|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.77|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.82|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med13|MED13]]|0.474|
|[[:human genes:m:med13l|MED13L]]|0.454|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.44|
|[[:human genes:c:ccnc|CCNC]]|0.44|
|[[:human genes:f:fnip1|FNIP1]]|0.433|
|[[:human genes:u:ube3a|UBE3A]]|0.429|
|[[:human genes:h:hdac8|HDAC8]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5453
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLK3 Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>