CLK3

Entrez Summary: N/A
UniProt Summary: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK626616 14μM R08 exp485	-5.35
Milciclib 2μM R08 exp502	-5.21
Dorsomorphin 5μM R07 exp357	-3.28
AICAR 240μM R03 exp116	-2.53
Oligomycin-A 2μM R00 exp25	-2.1
Wortmannin 5μM R00 exp38	-2.06
Sulforaphane 9μM R08 exp526 no dilution day6	-1.89
Ethanol 0.01 R05 exp234	-1.85
Sulforaphane 9μM R08 exp525	-1.8
Citral 50μM R06 exp274	-1.75
Pyridostatin 4μM R05 exp240	1.7
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Olaparib 4μM R08 exp512	1.76
Bafilomycin-A1 0.009μM R08 exp454	1.89
Deferoxamine 11μM R07 exp350	1.94
Vemurafenib 6.6μM R02 exp89	2
BN82002 4μM R07 exp340	2.01
Hydroxyurea 100μM R07 exp329	2.21
Clomiphene 4.4μM R02 exp68	2.77
Cerivastatin 0.15μM R05 exp226	2.82
TRAIL 50ng/ml R00 exp36	3.72
TRAIL 5ng/ml R00 exp35	4.56

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

protein serine/threonine/tyrosine kinase activity
intermediate filament cytoskeleton
acrosomal vesicle
protein tyrosine kinase activity
regulation of RNA splicing
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
protein autophosphorylation
protein serine/threonine kinase activity
nuclear speck
peptidyl-amino acid modification
protein phosphorylation
identical protein binding
phosphorylation
RNA binding
ATP binding
membrane