CLPX [The Human Chemical-Genetic Interaction Map Project]

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======= CLPX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLPX
  * **<color #00a2e8>Official Name</color>**: caseinolytic mitochondrial matrix peptidase chaperone subunit X
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10845|10845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76031|O76031]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLPX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLPX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP- dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689). {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:25957689}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ClpB D2-small|
|AAA|
|AAA 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial endopeptidase Clp complex|
|endopeptidase Clp complex|
|ATP-dependent peptidase activity|
|peptidase activator activity|
|mitochondrial nucleoid|
|unfolded protein binding|
|positive regulation of peptidase activity|
|ATP metabolic process|
|protein folding|
|ATPase activity|
|positive regulation of proteolysis|
|mitochondrial matrix|
|mitochondrial inner membrane|
|regulation of peptidase activity|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|ATP binding|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.73|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.82|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.84|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.35|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox8a|COX8A]]|0.485|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.472|
|[[:human genes:c:cluh|CLUH]]|0.464|
|[[:human genes:a:agpat5|AGPAT5]]|0.442|
|[[:human genes:p:pde12|PDE12]]|0.436|
|[[:human genes:n:nup205|NUP205]]|0.436|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.432|
|[[:human genes:p:paf1|PAF1]]|0.427|
|[[:human genes:t:txn2|TXN2]]|0.426|
|[[:human genes:z:zfand5|ZFAND5]]|0.409|
|[[:human genes:i:iscu|ISCU]]|0.407|
|[[:human genes:s:slc30a9|SLC30A9]]|0.405|
|[[:human genes:n:ndufb10|NDUFB10]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 769
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLPX Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>