CLPX

Official Symbol: CLPX
Official Name: caseinolytic mitochondrial matrix peptidase chaperone subunit X
Aliases and Previous Symbols: N/A
Entrez ID: 10845
UniProt: O76031
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082). Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477). ATP- dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689). {ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082, ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:25957689}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.73
Dimethyloxaloylglycine 100μM R05 exp229	1.82
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.84
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.9
Oligomycin-A 2μM R00 exp25	2.35
Clomiphene 4.4μM R02 exp68	2.51

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

mitochondrial endopeptidase Clp complex
endopeptidase Clp complex
ATP-dependent peptidase activity
peptidase activator activity
mitochondrial nucleoid
unfolded protein binding
positive regulation of peptidase activity
ATP metabolic process
protein folding
ATPase activity
positive regulation of proteolysis
mitochondrial matrix
mitochondrial inner membrane
regulation of peptidase activity
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
regulation of proteolysis
positive regulation of hydrolase activity
cellular macromolecule catabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
mitochondrion
proteolysis
regulation of hydrolase activity
positive regulation of catalytic activity
ATP binding
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
organic substance catabolic process
positive regulation of molecular function
cellular catabolic process