TXN2

Entrez Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity. {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052, ECO:0000269|PubMed:26626369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 10μM R06 exp288	1.83
Dimethyloxaloylglycine 100μM R05 exp229	2.07

peptide-methionine (S)-S-oxide reductase activity
peptide-methionine (R)-S-oxide reductase activity
glycerol ether metabolic process
sulfur amino acid catabolic process
ether metabolic process
protein disulfide oxidoreductase activity
sulfur amino acid metabolic process
response to axon injury
sulfur compound catabolic process
cell redox homeostasis
cellular amino acid catabolic process
response to glucose
response to hexose
response to monosaccharide
response to carbohydrate
cellular response to nutrient levels
cellular response to extracellular stimulus
carboxylic acid catabolic process
organic acid catabolic process
protein-containing complex binding
cellular amino acid metabolic process
cellular response to external stimulus
response to hypoxia
response to decreased oxygen levels
sulfur compound metabolic process
mitochondrial matrix
neuronal cell body
response to oxygen levels
response to oxidative stress
dendrite
small molecule catabolic process
response to nutrient levels
response to extracellular stimulus
response to wounding
nucleolus
cellular homeostasis
carboxylic acid metabolic process
response to hormone
response to organic cyclic compound
oxidation-reduction process