CLRN1

Entrez Summary: This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. {ECO:0000269|PubMed:12080385}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

equilibrioception
auditory receptor cell stereocilium organization
auditory receptor cell morphogenesis
basal part of cell
trans-Golgi network transport vesicle
auditory receptor cell development
positive regulation of lamellipodium assembly
inner ear auditory receptor cell differentiation
positive regulation of lamellipodium organization
inner ear receptor cell stereocilium organization
regulation of lamellipodium assembly
stereocilium
hair cell differentiation
photoreceptor cell maintenance
inner ear receptor cell development
regulation of lamellipodium organization
neuroepithelial cell differentiation
columnar/cuboidal epithelial cell development
inner ear receptor cell differentiation
neuromuscular process controlling balance
mechanoreceptor differentiation
microvillus
retina homeostasis
columnar/cuboidal epithelial cell differentiation
inner ear morphogenesis
positive regulation of plasma membrane bounded cell projection assembly
neuromuscular process
ear morphogenesis
sensory perception of sound
sensory perception of mechanical stimulus
lamellipodium
tissue homeostasis
epithelial cell development
inner ear development
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
visual perception
ear development
sensory perception of light stimulus
actin filament organization