CLSTN3

Entrez Summary: N/A
UniProt Summary: May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein localization to synapse
synaptic transmission, GABAergic
regulation of protein localization to synapse
regulation of presynapse assembly
synaptic transmission, glutamatergic
regulation of presynapse organization
integral component of postsynaptic density membrane
positive regulation of synapse assembly
GABA-ergic synapse
synapse assembly
regulation of synapse assembly
positive regulation of synaptic transmission
homophilic cell adhesion via plasma membrane adhesion molecules
postsynaptic membrane
regulation of synapse organization
regulation of synapse structure or activity
cell-cell adhesion via plasma-membrane adhesion molecules
synapse organization
glutamatergic synapse
regulation of cell growth
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
cell-cell adhesion
positive regulation of cellular component biogenesis
positive regulation of nervous system development
protein-containing complex
cell surface
Golgi membrane
regulation of growth
calcium ion binding
regulation of nervous system development
cell adhesion
biological adhesion
endoplasmic reticulum membrane
regulation of cellular component biogenesis
regulation of protein localization