CLUAP1

Entrez Summary: The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012].
UniProt Summary: Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intraciliary transport particle B
intraciliary transport involved in cilium assembly
ciliary tip
intraciliary transport
protein transport along microtubule
microtubule-based protein transport
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
protein-containing complex localization
microtubule-based movement
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
microtubule-based process
intracellular membrane-bounded organelle
organelle assembly
intracellular protein transport
plasma membrane bounded cell projection organization
cell projection organization
protein transport
intracellular transport
peptide transport
movement of cell or subcellular component
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport