CMPK2 [The Human Chemical-Genetic Interaction Map Project]

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======= CMPK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CMPK2
  * **<color #00a2e8>Official Name</color>**: cytidine/uridine monophosphate kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=129607|129607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5EBM0|Q5EBM0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CMPK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CMPK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611787|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thymidylate kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UMP kinase activity|
|thymidylate kinase activity|
|pyrimidine deoxyribonucleoside diphosphate metabolic process|
|dTDP biosynthetic process|
|dTDP metabolic process|
|dUDP biosynthetic process|
|pyrimidine deoxyribonucleoside diphosphate biosynthetic process|
|pyrimidine nucleoside diphosphate biosynthetic process|
|dUDP metabolic process|
|pyrimidine nucleoside diphosphate metabolic process|
|uridylate kinase activity|
|pyrimidine deoxyribonucleoside triphosphate biosynthetic process|
|dTTP biosynthetic process|
|cytidylate kinase activity|
|deoxyribonucleoside diphosphate biosynthetic process|
|dTTP metabolic process|
|deoxyribonucleoside triphosphate biosynthetic process|
|deoxyribonucleoside diphosphate metabolic process|
|pyrimidine deoxyribonucleoside triphosphate metabolic process|
|pyrimidine deoxyribonucleotide biosynthetic process|
|nucleoside diphosphate biosynthetic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|nucleoside monophosphate phosphorylation|
|deoxyribonucleotide biosynthetic process|
|deoxyribonucleoside triphosphate metabolic process|
|nucleoside diphosphate kinase activity|
|pyrimidine nucleoside triphosphate biosynthetic process|
|pyrimidine deoxyribonucleotide metabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|pyrimidine nucleotide biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside diphosphate phosphorylation|
|pyrimidine nucleotide metabolic process|
|nucleotide phosphorylation|
|nucleoside triphosphate biosynthetic process|
|nucleoside monophosphate metabolic process|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|pyrimidine-containing compound metabolic process|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|cellular response to lipid|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|response to bacterium|
|response to lipid|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|ATP binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10229
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CMPK2 Expression in NALM6 Cells: 1.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>