CMPK2

Gene Information

Official Symbol: CMPK2
Official Name: cytidine/uridine monophosphate kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 129607
UniProt: Q5EBM0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10229
Expression level (log2 read counts): 1.06

Expression Distribution

UMP kinase activity
thymidylate kinase activity
pyrimidine deoxyribonucleoside diphosphate metabolic process
dTDP biosynthetic process
dTDP metabolic process
dUDP biosynthetic process
pyrimidine deoxyribonucleoside diphosphate biosynthetic process
pyrimidine nucleoside diphosphate biosynthetic process
dUDP metabolic process
pyrimidine nucleoside diphosphate metabolic process
uridylate kinase activity
pyrimidine deoxyribonucleoside triphosphate biosynthetic process
dTTP biosynthetic process
cytidylate kinase activity
deoxyribonucleoside diphosphate biosynthetic process
dTTP metabolic process
deoxyribonucleoside triphosphate biosynthetic process
deoxyribonucleoside diphosphate metabolic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
pyrimidine deoxyribonucleotide biosynthetic process
nucleoside diphosphate biosynthetic process
2-deoxyribonucleotide biosynthetic process
deoxyribose phosphate biosynthetic process
nucleoside monophosphate phosphorylation
deoxyribonucleotide biosynthetic process
deoxyribonucleoside triphosphate metabolic process
nucleoside diphosphate kinase activity
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine deoxyribonucleotide metabolic process
pyrimidine nucleoside triphosphate metabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
nucleoside diphosphate phosphorylation
pyrimidine nucleotide metabolic process
nucleotide phosphorylation
nucleoside triphosphate biosynthetic process
nucleoside monophosphate metabolic process