CNBP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CNBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNBP
  * **<color #00a2e8>Official Name</color>**: CCHC-type zinc finger nucleic acid binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7555|7555]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62633|P62633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116955|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCHC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cytoplasmic translation|
|translation regulator activity|
|regulation of cytoplasmic translation|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|single-stranded RNA binding|
|sterol biosynthetic process|
|single-stranded DNA binding|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|positive regulation of translation|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|positive regulation of cellular amide metabolic process|
|mRNA binding|
|organic hydroxy compound biosynthetic process|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|steroid metabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|alcohol metabolic process|
|regulation of translation|
|regulation of cellular amide metabolic process|
|organic hydroxy compound metabolic process|
|posttranscriptional regulation of gene expression|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|DNA-binding transcription factor activity|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|endoplasmic reticulum|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.77|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.7|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.7|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.72|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.73|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.75|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.81|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.87|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.96|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.03|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.07|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.09|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.13|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.14|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.19|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.22|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.27|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.33|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.37|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.48|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.59|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.62|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.66|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.69|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|4.1|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|5.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps25|RPS25]]|0.434|
|[[:human genes:y:ylpm1|YLPM1]]|0.415|
|[[:human genes:p:ptma|PTMA]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15424
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNBP Expression in NALM6 Cells: 8.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>