CNBP

Gene Information

Official Symbol: CNBP
Official Name: CCHC-type zinc finger nucleic acid binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 7555
UniProt: P62633
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	-1.77
BI-6727 0.0125μM R03 exp97	-1.7
Staurosporine 0.02μM R08 exp524	1.7
Tunicamycin 0.04μM R07 exp418	1.7
2-Deoxy-D-glucose 800μM R05 exp214	1.72
Cerivastatin 0.15μM R05 exp226	1.73
Sulforaphane 9μM R08 exp526 no dilution day6	1.75
MS023 7μM R03 exp135	1.81
TRAIL 5ng/ml R00 exp35	1.87
Ethanol 0.01 R05 exp234	1.91
Rapamycin 10μM R00 exp30	1.96
AICAR 240μM R03 exp116	2.03
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.07
Radicicol 0.16μM R05 exp242	2.09
All-trans-Retinoic-Acid 40μM R07 exp334	2.13
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.14
Clomiphene 4.4μM R02 exp68	2.19
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.22
Sulforaphane 9μM R08 exp525	2.27
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.33
Olaparib 4μM R08 exp512	2.37
ML-792 0.2μM R08 exp505	2.48
MS023 2μM R03 exp134	2.59
GSK626616 14μM R08 exp485	2.62
AICAR 240μM R05 exp211	2.66
Arsenic trioxide 60μM R08 exp449	2.69
CB-5083 0.4μM R08 exp468	3.73
Arsenate 40μM R06 exp264	4.1
Bortezomib 0.005μM R00 exp6	5.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15424
Expression level (log2 read counts): 8.26

Expression Distribution

Gene	Correlation
RPS25	0.434
YLPM1	0.415
PTMA	0.41

positive regulation of cytoplasmic translation
translation regulator activity
regulation of cytoplasmic translation
cholesterol biosynthetic process
secondary alcohol biosynthetic process
single-stranded RNA binding
sterol biosynthetic process
single-stranded DNA binding
alcohol biosynthetic process
cholesterol metabolic process
positive regulation of translation
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
positive regulation of cellular amide metabolic process
mRNA binding
organic hydroxy compound biosynthetic process
DNA-binding transcription repressor activity, RNA polymerase II-specific
steroid metabolic process
RNA polymerase II regulatory region sequence-specific DNA binding
alcohol metabolic process
regulation of translation
regulation of cellular amide metabolic process
organic hydroxy compound metabolic process
posttranscriptional regulation of gene expression
lipid biosynthetic process
small molecule biosynthetic process
DNA-binding transcription factor activity
zinc ion binding
negative regulation of transcription by RNA polymerase II
positive regulation of cell population proliferation
endoplasmic reticulum
negative regulation of transcription, DNA-templated
lipid metabolic process
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process