CNGA2

Entrez Summary: The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010].
UniProt Summary: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Nicotinamide 2000μM R01 exp50	-2.22
Colchicine 0.009μM R05 exp215	1.72

cNMP binding
Ion trans

intracellular cGMP-activated cation channel activity
intracellular cAMP-activated cation channel activity
cGMP binding
Golgi-associated vesicle membrane
cAMP binding
ciliary membrane
calmodulin binding
sensory perception of smell
sensory perception of chemical stimulus
cation transmembrane transport
Golgi membrane
cation transport
ion transmembrane transport
sensory perception
transmembrane transport
ion transport
nervous system process
system process