CNGB1

Entrez Summary: In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
UniProt Summary: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intracellular cyclic nucleotide activated cation channel complex
transmembrane transporter complex
intracellular cGMP-activated cation channel activity
intracellular cAMP-activated cation channel activity
photoreceptor cell outer segment organization
rhodopsin mediated signaling pathway
ligand-gated ion channel activity
cGMP binding
detection of light stimulus involved in sensory perception
detection of light stimulus involved in visual perception
phototransduction, visible light
Golgi-associated vesicle membrane
cAMP binding
regulation of rhodopsin mediated signaling pathway
protein heterotetramerization
photoreceptor cell maintenance
phototransduction
photoreceptor cell development
detection of visible light
terminal bouton
ciliary membrane
photoreceptor cell differentiation
detection of light stimulus
photoreceptor outer segment
retina homeostasis
protein heterooligomerization
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
regulation of G protein-coupled receptor signaling pathway
protein tetramerization
cellular response to radiation
tissue homeostasis
visual perception
sensory perception of light stimulus
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
multicellular organismal homeostasis
regulation of cytosolic calcium ion concentration