CNN2

Entrez Summary: N/A
UniProt Summary: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 13/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	3/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CH
Calponin

interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
tertiary granule lumen
specific granule lumen
stress fiber
cellular response to mechanical stimulus
actomyosin structure organization
cell-cell junction
calmodulin binding
response to mechanical stimulus
actin binding
cadherin binding
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
cytoskeleton
regulation of actin filament-based process
focal adhesion
neutrophil degranulation
neutrophil activation involved in immune response
actin cytoskeleton organization
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
actin filament-based process
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
cytokine-mediated signaling pathway
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
cellular response to cytokine stimulus
export from cell