CNN3

Entrez Summary: N/A
UniProt Summary: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CH
Calponin

negative regulation of ATPase activity
cadherin binding involved in cell-cell adhesion
regulation of ATPase activity
cell-cell adherens junction
actomyosin structure organization
dendritic spine
calmodulin binding
actin cytoskeleton
microtubule binding
postsynaptic density
actin binding
neuronal cell body
focal adhesion
negative regulation of hydrolase activity
actin cytoskeleton organization
cell-cell adhesion
actin filament-based process
epithelial cell differentiation
negative regulation of catalytic activity
cell adhesion
biological adhesion
cytoskeleton organization
epithelium development
negative regulation of molecular function
regulation of hydrolase activity
tissue development