CNOT4 [The Human Chemical-Genetic Interaction Map Project]

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======= CNOT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNOT4
  * **<color #00a2e8>Official Name</color>**: CCR4-NOT transcription complex subunit 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4850|4850]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95628|O95628]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNOT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNOT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604911|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCR4-NOT complex|
|nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of megakaryocyte differentiation|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|protein autoubiquitination|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|cell cycle checkpoint|
|nuclear-transcribed mRNA catabolic process|
|negative regulation of mitotic cell cycle phase transition|
|mRNA catabolic process|
|regulation of myeloid cell differentiation|
|negative regulation of cell cycle phase transition|
|ubiquitin-protein transferase activity|
|RNA catabolic process|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|organic cyclic compound catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|mRNA metabolic process|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of cell cycle|
|proteolysis|
|cell cycle|
|RNA binding|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.4|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.26|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.25|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.22|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.2|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.08|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.07|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-2.03|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.96|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.83|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.82|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.76|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.72|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.71|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.73|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.75|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.81|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.84|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.02|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.03|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.35|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.7|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|4.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:srrd|SRRD]]|0.575|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.425|
|[[:human genes:v:vps29|VPS29]]|0.405|
|[[:human genes:p:pik3r4|PIK3R4]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNOT4 Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>