CNOT4

Gene Information

Official Symbol: CNOT4
Official Name: CCR4-NOT transcription complex subunit 4
Aliases and Previous Symbols: N/A
Entrez ID: 4850
UniProt: O95628
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Golgicide-A 4μM R03 exp122	-2.4
Thioridazine 5μM R08 exp530	-2.26
Hydroxychloroquine 30μM R08 exp490	-2.25
Vemurafenib 6.6μM R02 exp89	-2.22
TNF-alpha 44ng/ml R08 exp533	-2.2
Vemurafenib 6.6μM R08 exp434	-2.08
Nicotinamide 2000μM R01 exp50	-2.07
DKK1 89ng/ml R08 exp477	-2.03
Clomiphene 4.4μM R02 exp68	-1.96
Q15 1 to 2μM on day4 R04 exp164	-1.83
Chlorpromazine 10μM R07 exp344	-1.82
Trimetrexate 0.03μM R08 exp535	-1.76
BH1 1μM R04 exp169	-1.72
Monensin 0.3μM R08 exp507	-1.71
ML-792 0.2μM R08 exp505	1.71
Doxorubicin 0.02μM R08 exp478	1.73
MLN-4924 0.2μM R00 exp21	1.75
BI-D1870 3.15μM R02 exp66	1.78
Nutlin-3A 1.6μM R06 exp294	1.79
Milciclib 2μM R08 exp502	1.81
GSK626616 14μM R08 exp485	1.84
Methotrexate 0.01μM R08 exp501	2.02
SB202190 10μM R03 exp148	2.03
Arsenate 40μM R06 exp264	2.35
Olaparib 4μM R08 exp512	2.7
Aminopterin 0.005μM R07 exp335	4.28

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13789
Expression level (log2 read counts): 4.7

Expression Distribution

Gene	Correlation
SRRD	0.575
KIAA1033	0.425
VPS29	0.405
PIK3R4	0.405

CCR4-NOT complex
nuclear-transcribed mRNA poly(A) tail shortening
regulation of megakaryocyte differentiation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
mitotic G1 DNA damage checkpoint
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
protein autoubiquitination
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
mitotic DNA integrity checkpoint
signal transduction in response to DNA damage
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
signal transduction by p53 class mediator
DNA damage checkpoint
DNA integrity checkpoint
regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle checkpoint
regulation of cell cycle G1/S phase transition
cell cycle checkpoint
nuclear-transcribed mRNA catabolic process
negative regulation of mitotic cell cycle phase transition
mRNA catabolic process
regulation of myeloid cell differentiation
negative regulation of cell cycle phase transition
ubiquitin-protein transferase activity
RNA catabolic process
positive regulation of cell cycle process