CNOT7 [The Human Chemical-Genetic Interaction Map Project]

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======= CNOT7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNOT7
  * **<color #00a2e8>Official Name</color>**: CCR4-NOT transcription complex subunit 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29883|29883]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIV1|Q9UIV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNOT7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNOT7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604913|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAF1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host cell PML body|
|CCR4-NOT core complex|
|deadenylation-dependent decapping of nuclear-transcribed mRNA|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|poly(A)-specific ribonuclease activity|
|cytoplasmic mRNA processing body assembly|
|negative regulation of type I interferon-mediated signaling pathway|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|exoribonuclease activity|
|CCR4-NOT complex|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nuclear-transcribed mRNA poly(A) tail shortening|
|3-5-exoribonuclease activity|
|exonucleolytic catabolism of deadenylated mRNA|
|regulation of type I interferon-mediated signaling pathway|
|positive regulation of viral genome replication|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|gene silencing by miRNA|
|positive regulation of mRNA catabolic process|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|negative regulation of innate immune response|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|posttranscriptional gene silencing by RNA|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|posttranscriptional gene silencing|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of viral life cycle|
|negative regulation of cytokine-mediated signaling pathway|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|negative regulation of response to cytokine stimulus|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of mRNA metabolic process|
|DNA damage response, signal transduction by p53 class mediator|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of cell cycle arrest|
|P-body|
|gene silencing by RNA|
|negative regulation of response to biotic stimulus|
|regulation of viral genome replication|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|positive regulation of viral process|
|signal transduction by p53 class mediator|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of translation|
|DNA damage checkpoint|
|regulation of receptor signaling pathway via STAT|
|DNA integrity checkpoint|
|regulation of viral life cycle|
|negative regulation of cellular amide metabolic process|
|negative regulation of immune response|
|regulation of G1/S transition of mitotic cell cycle|
|gene silencing|
|mitotic cell cycle checkpoint|
|RNA phosphodiester bond hydrolysis|
|regulation of cytokine-mediated signaling pathway|
|regulation of cell cycle G1/S phase transition|
|regulation of response to cytokine stimulus|
|defense response to virus|
|cell cycle checkpoint|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of viral process|
|negative regulation of defense response|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of multi-organism process|
|mRNA catabolic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of cell cycle phase transition|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|transcription corepressor activity|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|response to virus|
|nuclear body|
|positive regulation of cell cycle process|
|nucleic acid phosphodiester bond hydrolysis|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|transcription factor binding|
|regulation of translation|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|nuclear speck|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|organic cyclic compound catabolic process|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|mRNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|regulation of defense response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|defense response to other organism|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|cell cycle|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.01|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.9|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.86|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.71|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNOT7 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>