CNOT7
Gene Information
- Official Symbol: CNOT7
- Official Name: CCR4-NOT transcription complex subunit 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 29883
- UniProt: Q9UIV1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
Pfam Domains GO Terms
Pfam Domains
| CAF1 |
GO Terms
| host cell PML body |
| CCR4-NOT core complex |
| deadenylation-dependent decapping of nuclear-transcribed mRNA |
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| poly(A)-specific ribonuclease activity |
| cytoplasmic mRNA processing body assembly |
| negative regulation of type I interferon-mediated signaling pathway |
| regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| exoribonuclease activity |
| CCR4-NOT complex |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| nuclear-transcribed mRNA poly(A) tail shortening |
| 3-5-exoribonuclease activity |
| exonucleolytic catabolism of deadenylated mRNA |
| regulation of type I interferon-mediated signaling pathway |
| positive regulation of viral genome replication |
| nuclear-transcribed mRNA catabolic process, exonucleolytic |
| RNA phosphodiester bond hydrolysis, exonucleolytic |
| gene silencing by miRNA |
| positive regulation of mRNA catabolic process |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| negative regulation of innate immune response |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| posttranscriptional gene silencing by RNA |
| signal transduction involved in mitotic DNA integrity checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| posttranscriptional gene silencing |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| positive regulation of viral life cycle |
| negative regulation of cytokine-mediated signaling pathway |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| negative regulation of response to cytokine stimulus |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of mRNA metabolic process |
| DNA damage response, signal transduction by p53 class mediator |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of cell cycle arrest |
| P-body |
| gene silencing by RNA |
| negative regulation of response to biotic stimulus |
| regulation of viral genome replication |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| mitotic DNA integrity checkpoint |
| signal transduction in response to DNA damage |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| positive regulation of viral process |
| signal transduction by p53 class mediator |
| regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of translation |
| DNA damage checkpoint |
| regulation of receptor signaling pathway via STAT |
| DNA integrity checkpoint |
| regulation of viral life cycle |
| negative regulation of cellular amide metabolic process |
| negative regulation of immune response |
| regulation of G1/S transition of mitotic cell cycle |
| gene silencing |
| mitotic cell cycle checkpoint |
| RNA phosphodiester bond hydrolysis |
| regulation of cytokine-mediated signaling pathway |
| regulation of cell cycle G1/S phase transition |
| regulation of response to cytokine stimulus |
| defense response to virus |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| regulation of mRNA catabolic process |
| regulation of viral process |
| negative regulation of defense response |
| negative regulation of mitotic cell cycle phase transition |
| negative regulation of multi-organism process |
| mRNA catabolic process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of cell cycle phase transition |
| ribonucleoprotein complex assembly |
| regulation of gene expression, epigenetic |
| transcription corepressor activity |
| ribonucleoprotein complex subunit organization |
| RNA catabolic process |
| regulation of peptidyl-tyrosine phosphorylation |
| response to virus |
| nuclear body |
| positive regulation of cell cycle process |
| nucleic acid phosphodiester bond hydrolysis |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| transcription factor binding |
| regulation of translation |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| nuclear speck |
| regulation of cellular amide metabolic process |
| regulation of mitotic cell cycle phase transition |
| positive regulation of catabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| negative regulation of immune system process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| regulation of innate immune response |
| ribonucleoprotein complex biogenesis |
| organic cyclic compound catabolic process |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| mRNA metabolic process |
| regulation of cell cycle process |
| organelle assembly |
| regulation of defense response |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| regulation of cellular catabolic process |
| cellular protein-containing complex assembly |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| positive regulation of cell population proliferation |
| defense response to other organism |
| regulation of catabolic process |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| regulation of immune response |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| cell cycle |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Caffeine 2600μM R08 exp463 | -2.01 |
| QNZ 0.01μM R08 exp439 | -1.9 |
| UMK57 0.6μM R03 exp107 | -1.86 |
| LB-100 4.1μM R02 exp72 | -1.71 |
| Rapamycin 1μM R00 exp29 | 2.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18466
- Expression level (log2 read counts): 6.42
Expression Distribution
CNOT7 Expression in NALM6 Cells: 6.42
