CNTN2 [The Human Chemical-Genetic Interaction Map Project]

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======= CNTN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNTN2
  * **<color #00a2e8>Official Name</color>**: contactin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6900|6900]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02246|Q02246]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNTN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNTN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. {ECO:0000269|PubMed:23518707}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
|fn3|
|ig|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of protein localization to juxtaparanode region of axon|
|anchored component of postsynaptic membrane|
|positive regulation of adenosine receptor signaling pathway|
|clustering of voltage-gated potassium channels|
|regulation of adenosine receptor signaling pathway|
|protein localization to juxtaparanode region of axon|
|regulation of axon diameter|
|cerebral cortex GABAergic interneuron migration|
|interneuron migration|
|cerebral cortex GABAergic interneuron development|
|interneuron migration from the subpallium to the cortex|
|protein localization to axon|
|juxtaparanode region of axon|
|cerebral cortex GABAergic interneuron differentiation|
|presynaptic membrane organization|
|substrate-independent telencephalic tangential migration|
|substrate-independent telencephalic tangential interneuron migration|
|neuronal ion channel clustering|
|regulation of cell projection size|
|GABAergic neuron differentiation|
|node of Ranvier|
|dendrite self-avoidance|
|cell-cell adhesion mediator activity|
|axon ensheathment in central nervous system|
|central nervous system myelination|
|neuron projection fasciculation|
|positive regulation of protein processing|
|axonal fasciculation|
|cerebral cortex neuron differentiation|
|positive regulation of protein maturation|
|regulation of astrocyte differentiation|
|positive regulation of G protein-coupled receptor signaling pathway|
|adult walking behavior|
|myelin sheath|
|forebrain neuron development|
|walking behavior|
|neuron maturation|
|oligodendrocyte development|
|neuron recognition|
|forebrain neuron differentiation|
|regulation of neuronal synaptic plasticity|
|protein self-association|
|telencephalon cell migration|
|forebrain cell migration|
|receptor internalization|
|regulation of protein processing|
|forebrain generation of neurons|
|regulation of protein maturation|
|oligodendrocyte differentiation|
|regulation of glial cell differentiation|
|adult locomotory behavior|
|central nervous system neuron development|
|receptor metabolic process|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|regulation of gliogenesis|
|neuron migration|
|anatomical structure maturation|
|regulation of G protein-coupled receptor signaling pathway|
|adult behavior|
|learning|
|cell maturation|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|glial cell differentiation|
|carbohydrate binding|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|locomotory behavior|
|gliogenesis|
|negative regulation of neuron differentiation|
|receptor-mediated endocytosis|
|cell recognition|
|developmental maturation|
|telencephalon development|
|learning or memory|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse|
|synapse organization|
|negative regulation of neurogenesis|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|negative regulation of cell development|
|positive regulation of proteolysis|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of anatomical structure size|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|endocytosis|
|cell morphogenesis involved in differentiation|
|behavior|
|cell surface|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of proteolysis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|vesicle-mediated transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4883
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNTN2 Expression in NALM6 Cells: 4.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>