CNTN2

Entrez Summary: This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. [provided by RefSeq, Sep 2016].
UniProt Summary: In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. {ECO:0000269|PubMed:23518707}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of protein localization to juxtaparanode region of axon
anchored component of postsynaptic membrane
positive regulation of adenosine receptor signaling pathway
clustering of voltage-gated potassium channels
regulation of adenosine receptor signaling pathway
protein localization to juxtaparanode region of axon
regulation of axon diameter
cerebral cortex GABAergic interneuron migration
interneuron migration
cerebral cortex GABAergic interneuron development
interneuron migration from the subpallium to the cortex
protein localization to axon
juxtaparanode region of axon
cerebral cortex GABAergic interneuron differentiation
presynaptic membrane organization
substrate-independent telencephalic tangential migration
substrate-independent telencephalic tangential interneuron migration
neuronal ion channel clustering
regulation of cell projection size
GABAergic neuron differentiation
node of Ranvier
dendrite self-avoidance
cell-cell adhesion mediator activity
axon ensheathment in central nervous system
central nervous system myelination
neuron projection fasciculation
positive regulation of protein processing
axonal fasciculation
cerebral cortex neuron differentiation
positive regulation of protein maturation
regulation of astrocyte differentiation
positive regulation of G protein-coupled receptor signaling pathway
adult walking behavior
myelin sheath
forebrain neuron development
walking behavior
neuron maturation
oligodendrocyte development
neuron recognition
forebrain neuron differentiation