CNTN4

Entrez Summary: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
UniProt Summary: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neuron cell-cell adhesion
dendrite self-avoidance
cell-cell adhesion mediator activity
neuron projection fasciculation
axonal fasciculation
neuron recognition
anchored component of membrane
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of synaptic plasticity
negative regulation of neuron differentiation
cell recognition
cell-cell adhesion via plasma-membrane adhesion molecules
axon guidance
neuron projection guidance
negative regulation of neurogenesis
axon
negative regulation of nervous system development
negative regulation of cell development
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell-cell adhesion
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
regulation of neuron differentiation
neuron projection development
negative regulation of cell differentiation
cell morphogenesis
brain development
head development
neuron development
regulation of neurogenesis
cellular component morphogenesis