COG1 [The Human Chemical-Genetic Interaction Map Project]

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======= COG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COG1
  * **<color #00a2e8>Official Name</color>**: component of oligomeric golgi complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9382|9382]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTW3|Q8WTW3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606973|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal Golgi function. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi transport complex|
|intra-Golgi vesicle-mediated transport|
|trans-Golgi network membrane|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|Golgi vesicle transport|
|endomembrane system organization|
|Golgi membrane|
|Golgi apparatus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.47|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.37|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.92|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.82|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cog4|COG4]]|0.538|
|[[:human genes:p:prim1|PRIM1]]|0.514|
|[[:human genes:c:cog3|COG3]]|0.49|
|[[:human genes:c:cog8|COG8]]|0.452|
|[[:human genes:c:cog7|COG7]]|0.418|
|[[:human genes:p:pi4kb|PI4KB]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COG1 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>